Brands :

Pamelor (Nortriptyline)

Category: Anti-Depressants ; Minimal price: 64 EUR

Available dose :

Commercial Name: Pamelor
Ingredient: Nortriptyline
Utilization: Treats depression
Available Dosage: 25mg

In general, depression is treated with a combination therapy of medication and psychotherapy. Regarding pharmacological treatment, there are currently many alternatives to address the disease.
Classical antidepressants are constituted by a central ring with seven elements and a terminal nitrogen that contains three elements (tertiary amines) and two elements (secondary amines). Tertiary amines include a wide range of types, while secondary amines include only three of them: desipramine, protriptyline, and nortriptyline.
What these drugs do is prevent the reuptake of serotonin, as well as norepinephrine, which, as a consequence, leads to an increase in the levels of both neurotransmitters in the brain.
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Pamelor (Generic) is an antidepressant with a pronounced sedative, anti-bacterial and anti-ulcer effect. ?�he drug is produced in the form of a solution and tablets.
Pamelor (Generic) is a tricyclic antidepressant, which belongs to the group of non-selective inhibitors of monoamine neuronal uptake. The mechanism of the antidepressant effect of the drug is due to the suppression of the reverse neuronal capture of catecholamines (dopamine, norepinephrine) and serotonin in the CNS.
Pamelor (Generic) binds to plasma proteins by 92?��96%, overcomes different barriers, including the blood-brain barrier (the same applies to nortriptyline) and the placental barrier, and is also detected in breast milk at concentrations similar to plasma.
For old people, the rate of Pamelor (Generic) metabolism is reduced, which leads to a decrease in the clearance of the drug.
Liver dysfunctions can provoke a slowdown in the rate of metabolic processes and an increase in the content of amitriptyline in the blood plasma. In patients with renal dysfunction, excretion of nortriptyline and Pamelor (Generic) metabolites slows down, but metabolic processes proceed in a similar way. Since Pamelor (Generic) binds well to plasma proteins, its removal from the body through dialysis is almost impossible.
Indications for the use of Pamelor (Generic) are:
Schizophrenic psychosis;
Emotional mixed disorders;
Behavior disorders;
Nocturnal enuresis (except that caused by low bladder tone);
Bulimia nervosa;
Chronic pains (a migraine, atypical facial pain, pain in cancer patients, post-traumatic and diabetic neuropathy, rheumatic pain, post-herpetic neuralgia).
The drug is also used in gastrointestinal ulcers, for relieving headaches and preventing migraines.
Contraindications of Pamelor (Generic) are:
Severe hypertension;
Acute diseases of the kidneys and liver;
Atony of the bladder;
Hypertrophy of the prostate gland;
Paralytic intestinal obstruction;
Hypersensitivity;
Pregnancy and lactation;
Age up to 6 years.